SURUFATINIB

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: B2K5L1L8S9

Structure
InChI Key TTZSNFLLYPYKIL-UHFFFAOYSA-N
Smile Cc1cc2cc(Oc3ccnc(Nc4cccc(CS(=O)(=O)NCCN(C)C)c4)n3)ccc2[nH]1
InChI
InChI=1S/C24H28N6O3S/c1-17-13-19-15-21(7-8-22(19)27-17)33-23-9-10-25-24(29-23)28-20-6-4-5-18(14-20)16-34(31,32)26-11-12-30(2)3/h4-10,13-15,26-27H,11-12,16H2,1-3H3,(H,25,28,29)

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H28N6O3S
Molecular Weight 480.59
AlogP 3.78
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 10.0
Polar Surface Area 112.24
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 34.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Fibroblast growth factor receptor 1 inhibitor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Axl family
- 4 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase FGFR family
- 15-15 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase PDGFR family
- 67-67 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Trk family
- 41-41 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase VEGFR family
- 1-1 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neuroendocrine Tumors 3 D018358 ClinicalTrials
Carcinoma, Neuroendocrine 3 D018278 ClinicalTrials
Neuroendocrine Tumors 3 D018358 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 2 D002289 ClinicalTrials
Head and Neck Neoplasms 2 D006258 ClinicalTrials
Carcinoma, Hepatocellular 2 D006528 ClinicalTrials
Stomach Neoplasms 2 D013274 ClinicalTrials
Sarcoma 2 D012509 ClinicalTrials
Small Cell Lung Carcinoma 2 D055752 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Osteosarcoma 2 D012516 ClinicalTrials
Nasopharyngeal Carcinoma 2 D000077274 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Biliary Tract Neoplasms 2 D001661 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Carcinoma 2 D002277 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Cholangiocarcinoma 2 D018281 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Sarcoma 2 D012509 ClinicalTrials
Triple Negative Breast Neoplasms 1 D064726 ClinicalTrials
Carcinoma, Pancreatic Ductal 1 D021441 ClinicalTrials
Liver Diseases 1 D008107 ClinicalTrials
Kidney Diseases 1 D007674 ClinicalTrials

Cross References

Resources Reference
CAS NUMBER 1308672-74-3
ChEMBL CHEMBL4297190
DrugBank DB15106
FDA SRS B2K5L1L8S9
Guide to Pharmacology 9769
PubChem 52920501
SureChEMBL SCHEMBL1822601
ZINC ZINC000117218067
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