SUTEZOLID

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Synonyms:	NSC-742407 Oxazolidininone PNU-100480 Sutezolid U 100480 U-100480
Status:	Phase 2
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	3A71182L8P

Structure


InChI Key	FNDDDNOJWPQCBZ-ZDUSSCGKSA-N
Smile	CC(=O)NC[C@H]1CN(c2ccc(N3CCSCC3)c(F)c2)C(=O)O1
InChI	InChI=1S/C16H20FN3O3S/c1-11(21)18-9-13-10-20(16(22)23-13)12-2-3-15(14(17)8-12)19-4-6-24-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C16H20FN3O3S
Molecular Weight	353.42
AlogP	1.84
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	4.0
Polar Surface Area	61.88
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	24.0

Pharmacology

Action	Mechanism of Action	Reference
INHIBITOR	70S ribosome inhibitor	PubMed PubMed PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Oxidoreductase	-	13000	-	-	-

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Tuberculosis	2	D014376	ClinicalTrials
Tuberculosis, Pulmonary	2	D014397	ClinicalTrials

Related Entries

MCS

Target Level :

Level 3

Level 4

Level 5

Level 6

Extend :

Indication

Mechanism of Action

Primary Target

Target Level

Cross References

Resources	Reference
CAS NUMBER	168828-58-8
ChEMBL	CHEMBL288149
DrugBank	DB11905
EPA CompTox	DTXSID20168611
FDA SRS	3A71182L8P
PDB	9EN
PubChem	465951
SureChEMBL	SCHEMBL2152517
ZINC	ZINC000003810825

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