SUVN-G3031

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Synonyms:	Samelisant Suvn-g3031 SUVN-G3031 FREE BASE
Status:	Phase 2
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	65V47O9NOP

Structure


InChI Key	LNXDUSQEXVQFGP-UHFFFAOYSA-N
Smile	O=C(CN1CCOCC1)Nc1ccc(OC2CCN(C3CCC3)CC2)cc1
InChI	InChI=1S/C21H31N3O3/c25-21(16-23-12-14-26-15-13-23)22-17-4-6-19(7-5-17)27-20-8-10-24(11-9-20)18-2-1-3-18/h4-7,18,20H,1-3,8-16H2,(H,22,25)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C21H31N3O3
Molecular Weight	373.5
AlogP	2.35
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	6.0
Polar Surface Area	54.04
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	27.0

Pharmacology

Action	Mechanism of Action	Reference
INVERSE AGONIST	Histamine H3 receptor inverse agonist	PubMed PubMed PubMed

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Narcolepsy	2	D009290	ClinicalTrials
Cognitive Dysfunction	1	D060825	ClinicalTrials

Related Entries

Scaffolds

Target Level :

Level 3

Level 4

Level 5

Level 6

Extend network:

Indication

Mechanism of Action

Primary Target

Target Level

Cross References

Resources	Reference
CAS NUMBER	1394808-82-2
ChEMBL	CHEMBL4297328
DrugBank	DB14835
FDA SRS	65V47O9NOP
Guide to Pharmacology	10232
SureChEMBL	SCHEMBL12484542

CONTENTS