TALAMPANEL

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: CVS43XG1L5

Structure
InChI Key JACAAXNEHGBPOQ-LLVKDONJSA-N
Smile CC(=O)N1N=C(c2ccc(N)cc2)c2cc3c(cc2C[C@H]1C)OCO3
InChI
InChI=1S/C19H19N3O3/c1-11-7-14-8-17-18(25-10-24-17)9-16(14)19(21-22(11)12(2)23)13-3-5-15(20)6-4-13/h3-6,8-9,11H,7,10,20H2,1-2H3/t11-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H19N3O3
Molecular Weight 337.38
AlogP 2.54
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 1.0
Polar Surface Area 77.15
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 25.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Glutamate receptor ionotropic, AMPA 1 antagonist PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Amyotrophic Lateral Sclerosis 2 D000690 ClinicalTrials
Epilepsy 2 D004827 ClinicalTrials
Glioblastoma 2 D005909 ClinicalTrials
Oligodendroglioma 2 D009837 ClinicalTrials
Astrocytoma 2 D001254 ClinicalTrials
Oligodendroglioma 2 D009837 ClinicalTrials
Parkinson Disease 2 D010300 ClinicalTrials
Central Nervous System Neoplasms 2 D016543 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 161832-65-1
ChEBI 34992
ChEMBL CHEMBL61872
DrugBank DB04982
EPA CompTox DTXSID10167259
FDA SRS CVS43XG1L5
Guide to Pharmacology 8279
KEGG C13670
PubChem 164509
SureChEMBL SCHEMBL118011
ZINC ZINC000003823565
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