TEGAFUR

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: Parent
ATC: L01BC03
UNII: 1548R74NSZ

Structure
InChI Key WFWLQNSHRPWKFK-UHFFFAOYSA-N
Smile O=c1[nH]c(=O)n(C2CCCO2)cc1F
InChI
InChI=1S/C8H9FN2O3/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13)

Physicochemical Descriptors

Property Name Value
Molecular Formula C8H9FN2O3
Molecular Weight 200.17
AlogP -0.02
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 1.0
Polar Surface Area 64.09
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 14.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR DNA inhibitor EMA

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neoplasms 4 D009369 ClinicalTrials
Pancreatic Neoplasms 3 D010190 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Colorectal Neoplasms 3 D015179 ClinicalTrials
Cholangiocarcinoma 3 D018281 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Rectal Neoplasms 3 D012004 ClinicalTrials
Colorectal Neoplasms 3 D015179 ClinicalTrials
Colorectal Neoplasms 3 D015179 ClinicalTrials
Adenocarcinoma 3 D000230 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Urinary Bladder Neoplasms 3 D001749 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Rectal Neoplasms 3 D012004 ClinicalTrials
Colorectal Neoplasms 3 D015179 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Pancreatic Neoplasms 3 D010190 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Neuroendocrine Tumors 2 D018358 ClinicalTrials
Carcinoma, Squamous Cell 2 D002294 ClinicalTrials
Neuroendocrine Tumors 2 D018358 ClinicalTrials
Carcinoma, Pancreatic Ductal 2 D021441 ClinicalTrials
Carcinoma, Neuroendocrine 2 D018278 ClinicalTrials
Small Cell Lung Carcinoma 2 D055752 ClinicalTrials
Squamous Cell Carcinoma of Head and Neck 2 D000077195 ClinicalTrials
Carcinoma, Hepatocellular 2 D006528 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 2 D002289 ClinicalTrials
Biliary Tract Neoplasms 2 D001661 ClinicalTrials
Gallbladder Neoplasms 2 D005706 ClinicalTrials
Biliary Tract Neoplasms 2 D001661 ClinicalTrials
Nasopharyngeal Neoplasms 2 D009303 ClinicalTrials
Liver Diseases 1 D008107 ClinicalTrials
Kidney Diseases 1 D007674 ClinicalTrials
Uterine Cervical Neoplasms 1 D002583 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 17902-23-7
ChEBI 32188
ChEMBL CHEMBL20883
DrugBank DB09256
DrugCentral 4398
EPA CompTox DTXSID8021305
FDA SRS 1548R74NSZ
Guide to Pharmacology 10513
KEGG C12673
PubChem 5386
SureChEMBL SCHEMBL4552
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