TELATINIB

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: Parent
UNII: 18P7197Q7J

Structure
InChI Key QFCXANHHBCGMAS-UHFFFAOYSA-N
Smile CNC(=O)c1cc(COc2nnc(Nc3ccc(Cl)cc3)c3ccoc23)ccn1
InChI
InChI=1S/C20H16ClN5O3/c1-22-19(27)16-10-12(6-8-23-16)11-29-20-17-15(7-9-28-17)18(25-26-20)24-14-4-2-13(21)3-5-14/h2-10H,11H2,1H3,(H,22,27)(H,24,25)

Physicochemical Descriptors

Property Name Value
Molecular Formula C20H16ClN5O3
Molecular Weight 409.83
AlogP 3.95
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 6.0
Polar Surface Area 102.17
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 29.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Platelet-derived growth factor receptor beta inhibitor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase MLK family TKL protein kinase ILK subfamily
- - 32 - -
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase MLK family TKL protein kinase MLK subfamily
- - 477 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase PDGFR family
- 1 555 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase VEGFR family
- 6-6 - - -
Enzyme Transferase
- - - - -0.1519-12.52
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- - - - -31.7--0.52

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Stomach Neoplasms 2 D013274 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials

Related Entries

Scaffolds

Salt

Cross References

Resources Reference
CAS NUMBER 332012-40-5
ChEMBL CHEMBL2079588
DrugBank DB15393
FDA SRS 18P7197Q7J
Guide to Pharmacology 10476
PharmGKB PA165980595
PubChem 9808844
SureChEMBL SCHEMBL1250560
ZINC ZINC000000590964
CONTENTS