TIAPRIDE

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: Parent
ATC: N05AL03
UNII: LAH70H9JPH

Structure
InChI Key JTVPZMFULRWINT-UHFFFAOYSA-N
Smile CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC
InChI
InChI=1S/C15H24N2O4S/c1-5-17(6-2)10-9-16-15(18)13-11-12(22(4,19)20)7-8-14(13)21-3/h7-8,11H,5-6,9-10H2,1-4H3,(H,16,18)

Physicochemical Descriptors

Property Name Value
Molecular Formula C15H24N2O4S
Molecular Weight 328.43
AlogP 1.17
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 8.0
Polar Surface Area 75.71
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 22.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Dopamine D2 receptor antagonist Other PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- - - - 3.198
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- - - - -4.78-5.83
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor
- 2078 - 779 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor
- 1149 - 390 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Schizophrenia 3 D012559 ClinicalTrials
Anxiety 3 D001007 ClinicalTrials
Dementia 3 D003704 ClinicalTrials
Tourette Syndrome 3 D005879 ClinicalTrials
Depressive Disorder 3 D003866 ClinicalTrials

Related Entries

MCS

Cross References

Resources Reference
CAS NUMBER 51012-32-9
ChEBI 94666
ChEMBL CHEMBL84158
DrugBank DB13025
DrugCentral 2651
EPA CompTox DTXSID0023664
FDA SRS LAH70H9JPH
Human Metabolome Database HMDB0042039
PubChem 5467
SureChEMBL SCHEMBL34750
ZINC ZINC000001542927
CONTENTS