TRIFLUOPERAZINE

Search structure
Synonyms:
Status: Approved (1959)
Entry Type: Small molecule
Molecule Category: Parent
ATC: N05AB06
UNII: 214IZI85K3

Structure
InChI Key ZEWQUBUPAILYHI-UHFFFAOYSA-N
Smile CN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1
InChI
InChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C21H24F3N3S
Molecular Weight 407.51
AlogP 4.95
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 4.0
Polar Surface Area 9.72
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 28.0

Pharmacology

Primary Target
D2 receptor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- 45000 - - -
Enzyme Isomerase
- - - 500 -
Enzyme Kinase Protein Kinase Atypical protein kinase group Atypical protein kinase PIKK family
- 100000 - - -
Enzyme Oxidoreductase
- 72000 - 23000 -
Enzyme Protease Cysteine protease Cysteine protease CA clan Cysteine protease C19 family
- 8000 - - -
Epigenetic regulator Reader Methyl-lysine/arginine binding protein WDR domain
- 8000 - - -
Ion channel Voltage-gated ion channel Voltage-gated sodium channel
- 5000 - - 80
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor
- 350 - 29 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor
- 16 1 2 73
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
- - 1 411 -
Membrane receptor
- 16 1 15 73
Secreted protein
- - 14000 - -
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 4
- - - - 3
Transporter Primary active transporter ATP-binding cassette ABCB subfamily
- - - 6500 -
Transporter Primary active transporter P-type ATPase Calcium ATPase
- 45000 - - -
Transporter
- 1400 - 6500 -
Unclassified protein
- 700 3400-5000 4 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

Scaffolds

Salt

Cross References

Resources Reference
CAS NUMBER 117-89-5
ChEBI 45951
ChEMBL CHEMBL422
DrugBank DB00831
DrugCentral 2740
EPA CompTox DTXSID1046928
FDA SRS 214IZI85K3
Human Metabolome Database HMDB0014969
Guide to Pharmacology 214
KEGG C07168
PDB TFP
PharmGKB PA451771
PubChem 5566
SureChEMBL SCHEMBL24866
ZINC ZINC000019418959
CONTENTS