TROXACITABINE

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 60KQZ0388Y

Structure
InChI Key RXRGZNYSEHTMHC-BQBZGAKWSA-N
Smile Nc1ccn([C@@H]2CO[C@H](CO)O2)c(=O)n1
InChI
InChI=1S/C8H11N3O4/c9-5-1-2-11(8(13)10-5)6-4-14-7(3-12)15-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C8H11N3O4
Molecular Weight 213.19
AlogP -1.31
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 2.0
Polar Surface Area 99.6
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 15.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR DNA polymerase (alpha/delta/epsilon) inhibitor PubMed PubMed PubMed PubMed PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Leukemia 2 D007938 ClinicalTrials

Cross References

Resources Reference
CAS NUMBER 145918-75-8
ChEBI 134886
ChEMBL CHEMBL359164
DrugBank DB04961
DrugCentral 3635
FDA SRS 60KQZ0388Y
PDB LTT
PubChem 454194
SureChEMBL SCHEMBL18548
ZINC ZINC000001642845
CONTENTS