VERINURAD

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 12WJ62D047

Structure
InChI Key YYBOLPLTQDKXPM-UHFFFAOYSA-N
Smile CC(C)(Sc1ccncc1-c1ccc(C#N)c2ccccc12)C(=O)O
InChI
InChI=1S/C20H16N2O2S/c1-20(2,19(23)24)25-18-9-10-22-12-17(18)16-8-7-13(11-21)14-5-3-4-6-15(14)16/h3-10,12H,1-2H3,(H,23,24)

Physicochemical Descriptors

Property Name Value
Molecular Formula C20H16N2O2S
Molecular Weight 348.43
AlogP 4.73
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 4.0
Polar Surface Area 73.98
Molecular species ACID
Aromatic Rings 3.0
Heavy Atoms 25.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Solute carrier family 22 member 12 inhibitor PubMed Other PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters
- 23-25 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Gout 2 D006073 ClinicalTrials
Renal Insufficiency, Chronic 2 D051436 ClinicalTrials
Heart Failure 2 D006333 ClinicalTrials
Hyperuricemia 2 D033461 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 1352792-74-5
ChEMBL CHEMBL3707347
DrugBank DB11873
FDA SRS 12WJ62D047
Guide to Pharmacology 9327
PubChem 54767229
SureChEMBL SCHEMBL12070797
ZINC ZINC000199107019
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