ZOLIFLODACIN

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: FWL2263R77

Structure
InChI Key ZSWMIFNWDQEXDT-ZESJGQACSA-N
Smile C[C@@H]1O[C@H](C)CN2c3c(cc4c(N5C(=O)OC[C@@H]5C)noc4c3F)CC3(C(=O)NC(=O)NC3=O)[C@@H]12
InChI
InChI=1S/C22H22FN5O7/c1-8-7-33-21(32)28(8)17-12-4-11-5-22(18(29)24-20(31)25-19(22)30)16-10(3)34-9(2)6-27(16)14(11)13(23)15(12)35-26-17/h4,8-10,16H,5-7H2,1-3H3,(H2,24,25,29,30,31)/t8-,9+,10-,16+/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C22H22FN5O7
Molecular Weight 487.44
AlogP 1.2
Hydrogen Bond Acceptor 9.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 1.0
Polar Surface Area 143.31
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 35.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR DNA gyrase inhibitor PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Gonorrhea 3 D006069 ClinicalTrials
Infections 1 D007239 ClinicalTrials

Cross References

Resources Reference
CAS NUMBER 1620458-09-4
ChEMBL CHEMBL3544978
DrugBank DB12817
FDA SRS FWL2263R77
Guide to Pharmacology 10875
PubChem 76685216
SureChEMBL SCHEMBL15879500
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