ZUCAPSAICIN

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: M02AB02
UNII: 15OX67P384

Structure
InChI Key YKPUWZUDDOIDPM-VURMDHGXSA-N
Smile COc1cc(CNC(=O)CCCC/C=C\C(C)C)ccc1O
InChI
InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6-

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H27NO3
Molecular Weight 305.42
AlogP 3.79
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 9.0
Polar Surface Area 58.56
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 22.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Vanilloid receptor agonist EMA PubMed Other PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Voltage-gated ion channel Transient receptor potential channel
28 - - 1080 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Osteoarthritis, Knee 3 D020370 ClinicalTrials
Pain 3 D010146 ClinicalTrials
Dry Eye Syndromes 2 D015352 ClinicalTrials
Neuralgia, Postherpetic 2 D051474 ClinicalTrials

Cross References

Resources Reference
CAS NUMBER 25775-90-0
ChEBI 135952
ChEMBL CHEMBL313971
DrugBank DB09120
DrugCentral 4342
FDA SRS 15OX67P384
PubChem 1548942
SureChEMBL SCHEMBL41210
ZINC ZINC000004468952
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