AZD1386

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 210323T9CP

Structure
InChI Key DXDVSYALLVVBOV-UHFFFAOYSA-N
Smile Cc1cc(Cl)cc2c1N(Cc1cccc(C(F)(F)F)c1)C(=O)C21NC(=O)NC1=O
InChI
InChI=1S/C19H13ClF3N3O3/c1-9-5-12(20)7-13-14(9)26(16(28)18(13)15(27)24-17(29)25-18)8-10-3-2-4-11(6-10)19(21,22)23/h2-7H,8H2,1H3,(H2,24,25,27,29)

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H13ClF3N3O3
Molecular Weight 423.78
AlogP 3.25
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 2.0
Polar Surface Area 78.51
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 29.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Vanilloid receptor antagonist PubMed
Primary Target
TRPV1

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neuralgia 2 D009437 ClinicalTrials
Pain 2 D010146 ClinicalTrials
Chronic Pain 1 D059350 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL3545039
FDA SRS 210323T9CP
Guide to Pharmacology 7820
SureChEMBL SCHEMBL4257077
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