VERICIGUAT

Search structure
Synonyms:
Status: Approved (2021)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: C01DX22
UNII: LV66ADM269

Structure
InChI Key QZFHIXARHDBPBY-UHFFFAOYSA-N
Smile COC(=O)Nc1c(N)nc(-c2nn(Cc3ccccc3F)c3ncc(F)cc23)nc1N
InChI
InChI=1S/C19H16F2N8O2/c1-31-19(30)25-14-15(22)26-17(27-16(14)23)13-11-6-10(20)7-24-18(11)29(28-13)8-9-4-2-3-5-12(9)21/h2-7H,8H2,1H3,(H,25,30)(H4,22,23,26,27)

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H16F2N8O2
Molecular Weight 426.39
AlogP 2.56
Hydrogen Bond Acceptor 9.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 4.0
Polar Surface Area 146.86
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 31.0

Pharmacology

Action Mechanism of Action Reference
ACTIVATOR Soluble guanylate cyclase activator FDA PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Heart Failure 4 D006333 ClinicalTrials
Coronary Disease 1 D003327 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 1350653-20-1
ChEBI 142432
ChEMBL CHEMBL4066936
DrugBank DB15456
FDA SRS LV66ADM269
Guide to Pharmacology 10010
PubChem 54674461
SureChEMBL SCHEMBL429958
ZINC ZINC000072318626
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