| Synonyms: | |
| Status: | Phase 3 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | CJN36EQM0H |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C32H31ClN6O3 |
| Molecular Weight | 583.09 |
| AlogP | 6.47 |
| Hydrogen Bond Acceptor | 8.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 10.0 |
| Polar Surface Area | 112.4 |
| Molecular species | None |
| Aromatic Rings | 4.0 |
| Heavy Atoms | 42.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Epidermal growth factor receptor erbB1 inhibitor | Other |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase EGFR family
|
- | 0.48-45 | - | - | - | |
|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase Tec family
|
- | 31.7 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Breast Neoplasms | 3 | D001943 | ClinicalTrials |
| Breast Neoplasms | 3 | D001943 | ClinicalTrials |
| Carcinoma, Non-Small-Cell Lung | 3 | D002289 | ClinicalTrials |
| Digestive System Neoplasms | 2 | D004067 | ClinicalTrials |
| Neoplasms | 2 | D009369 | ClinicalTrials |
| Colorectal Neoplasms | 2 | D015179 | ClinicalTrials |
| Triple Negative Breast Neoplasms | 1 | D064726 | ClinicalTrials |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive | 1 | D015464 | ClinicalTrials |
| Stomach Neoplasms | 1 | D013274 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 1269662-73-8 |
| ChEMBL | CHEMBL3544956 |
| FDA SRS | CJN36EQM0H |
| Guide to Pharmacology | 9662 |
| PubChem | 51039030 |
CONTENTS