Synonyms: | |
Status: | Approved (1985) |
Entry Type: | Small molecule |
Molecule Category: | Parent Prodrug |
ATC: | C09AA02 |
UNII: | 69PN84IO1A |
InChI Key | GBXSMTUPTTWBMN-XIRDDKMYSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C20H28N2O5 |
Molecular Weight | 376.45 |
AlogP | 1.6 |
Hydrogen Bond Acceptor | 5.0 |
Hydrogen Bond Donor | 2.0 |
Number of Rotational Bond | 9.0 |
Polar Surface Area | 95.94 |
Molecular species | ACID |
Aromatic Rings | 1.0 |
Heavy Atoms | 27.0 |
Property Name | Value | Unit | Method |
---|---|---|---|
log P (octanol-water) | 2.450 | - | EST |
Atmospheric OH Rate Constant | 1.18E-10 | cm3/molecule-sec | EST |
Water Solubility | 1.64E+04 | mg/L | EXP |
Primary Target | |
---|---|
Angiotensin-converting enzyme |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Neoplasms | 3 | D009369 | ClinicalTrials |
Cardiomyopathies | 3 | D009202 | ClinicalTrials |
Leukemia, Myeloid, Acute | 3 | D015470 | ClinicalTrials |
Heart Failure | 3 | D006333 | ClinicalTrials |
Hypertension | 3 | D006973 | ClinicalTrials |
Multiple Myeloma | 3 | D009101 | ClinicalTrials |
Heart Failure | 3 | D006333 | ClinicalTrials |
Leukemia, Lymphoid | 3 | D007945 | ClinicalTrials |
Myocardial Ischemia | 3 | D017202 | ClinicalTrials |
Cardiotoxicity | 3 | D066126 | ClinicalTrials |
Severe Acute Respiratory Syndrome | 3 | D045169 | ClinicalTrials |
Chagas Cardiomyopathy | 3 | D002598 | ClinicalTrials |
ST Elevation Myocardial Infarction | 3 | D000072657 | ClinicalTrials |
Glomerulonephritis, IGA | 2 | D005922 | ClinicalTrials |
Diabetes Mellitus, Type 1 | 2 | D003922 | ClinicalTrials |
Essential Hypertension | 2 | D000075222 | ClinicalTrials |
Stroke | 2 | D020521 | ClinicalTrials |
Heart Diseases | 2 | D006331 | ClinicalTrials |
Pseudohypoaldosteronism | 2 | D011546 | ClinicalTrials |
Cerebral Hemorrhage | 2 | D002543 | ClinicalTrials |
Melanoma | 2 | D008545 | ClinicalTrials |
Erectile Dysfunction | 1 | D007172 | ClinicalTrials |
Ischemia | 1 | D007511 | ClinicalTrials |
Renal Insufficiency, Chronic | 1 | D051436 | ClinicalTrials |
Barrett Esophagus | 0 | D001471 | ClinicalTrials |
Resources | Reference |
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CAS NUMBER | 75847-73-3 |
ChEBI | 4784 |
ChEMBL | CHEMBL578 |
DrugBank | DB00584 |
DrugCentral | 1005 |
EPA CompTox | DTXSID5022982 |
FDA SRS | 69PN84IO1A |
Human Metabolome Database | HMDB0014722 |
Guide to Pharmacology | 6322 |
KEGG | C06977 |
PubChem | 5388962 |
SureChEMBL | SCHEMBL18 |
ZINC | ZINC000003791297 |