EPROSARTAN

Search structure
Synonyms:
Status: Approved (1997)
Entry Type: Small molecule
Molecule Category: Parent
ATC: C09CA02
UNII: 2KH13Z0S0Y

Structure
InChI Key OROAFUQRIXKEMV-LDADJPATSA-N
Smile CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1
InChI
InChI=1S/C23H24N2O4S/c1-2-3-6-21-24-14-19(12-18(23(28)29)13-20-5-4-11-30-20)25(21)15-16-7-9-17(10-8-16)22(26)27/h4-5,7-12,14H,2-3,6,13,15H2,1H3,(H,26,27)(H,28,29)/b18-12+

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H24N2O4S
Molecular Weight 424.52
AlogP 4.74
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 10.0
Polar Surface Area 92.42
Molecular species ACID
Aromatic Rings 3.0
Heavy Atoms 30.0

Pharmacology

Primary Target
AT1 receptor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Angiotensin receptor
- 1-9 - - -
Transporter Primary active transporter ATP-binding cassette ABCC subfamily
- 57900 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Essential Hypertension 3 D000075222 ClinicalTrials
Kidney Diseases 1 D007674 ClinicalTrials

Related Entries

Salt

Cross References

Resources Reference
CAS NUMBER 133040-01-4
ChEBI 4814
ChEMBL CHEMBL813
DrugBank DB00876
DrugCentral 1037
EPA CompTox DTXSID0022989
FDA SRS 2KH13Z0S0Y
Human Metabolome Database HMDB0015014
Guide to Pharmacology 3940
PubChem 5281037
SureChEMBL SCHEMBL4025
ZINC ZINC000029319828
CONTENTS