PF-06651600

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 2OYE00PC25

Structure
InChI Key CBRJPFGIXUFMTM-WDEREUQCSA-N
Smile C=CC(=O)N1C[C@H](Nc2ncnc3[nH]ccc23)CC[C@@H]1C
InChI
InChI=1S/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C15H19N5O
Molecular Weight 285.35
AlogP 1.94
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 73.91
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 21.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR TEC family kinase inhibitor PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase EGFR family
- 25200 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase JakA family
- 0-202 - 6310 -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase JakB family
- 0-202 - 6310 -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Src family
- 19000 - 32400 -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Tec family
- 193 - 131 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Alopecia Areata 3 D000506 ClinicalTrials
Arthritis, Rheumatoid 2 D001172 ClinicalTrials
Colitis, Ulcerative 2 D003093 ClinicalTrials
Crohn Disease 2 D003424 ClinicalTrials
Vitiligo 2 D014820 ClinicalTrials
Liver Diseases 1 D008107 ClinicalTrials
Kidney Diseases 1 D007674 ClinicalTrials

Cross References

Resources Reference
CAS NUMBER 1792180-81-4
ChEMBL CHEMBL4085457
DrugBank DB14924
FDA SRS 2OYE00PC25
Guide to Pharmacology 9559
SureChEMBL SCHEMBL16764638
ZINC ZINC000526061581
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