| Synonyms: | |
| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | 63FJ7LF55O |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C25H28N6O3 |
| Molecular Weight | 460.54 |
| AlogP | 3.9 |
| Hydrogen Bond Acceptor | 8.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 4.0 |
| Polar Surface Area | 117.16 |
| Molecular species | None |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 34.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| ANTAGONIST | Transient receptor potential cation channel subfamily V member 4 antagonist |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Hydrolase
|
- | - | - | - | 10.49 | |
|
Enzyme
|
- | - | - | - | 10.49 | |
|
Ion channel
Voltage-gated ion channel
Transient receptor potential channel
|
- | 1.8-2 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Heart Failure | 2 | D006333 | ClinicalTrials |
| Pulmonary Edema | 2 | D011654 | ClinicalTrials |
| Heart Failure | 2 | D006333 | ClinicalTrials |
| Cough | 1 | D003371 | ClinicalTrials |
| Macular Edema | 1 | D008269 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL3707225 |
| FDA SRS | 63FJ7LF55O |
CONTENTS