AZD1981

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 2AD53WQ2CX

Structure
InChI Key JWYIGNODXSRKGP-UHFFFAOYSA-N
Smile CC(=O)Nc1cccc2c1c(Sc1ccc(Cl)cc1)c(C)n2CC(=O)O
InChI
InChI=1S/C19H17ClN2O3S/c1-11-19(26-14-8-6-13(20)7-9-14)18-15(21-12(2)23)4-3-5-16(18)22(11)10-17(24)25/h3-9H,10H2,1-2H3,(H,21,23)(H,24,25)

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H17ClN2O3S
Molecular Weight 388.88
AlogP 4.8
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 5.0
Polar Surface Area 71.33
Molecular species ACID
Aromatic Rings 3.0
Heavy Atoms 26.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST G protein-coupled receptor 44 antagonist PubMed Other
Primary Target
DP2 receptor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Oxidoreductase
- 794 - - -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Lipid-like ligand receptor (family A GPCR) Prostanoid receptor
- 4-10 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Pulmonary Disease, Chronic Obstructive 2 D029424 ClinicalTrials
Asthma 2 D001249 ClinicalTrials
Urticaria 2 D014581 ClinicalTrials
Infertility 1 D007246 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL1914489
DrugBank DB11946
FDA SRS 2AD53WQ2CX
Guide to Pharmacology 7680
SureChEMBL SCHEMBL1053662
ZINC ZINC000073196066
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