LAROPIPRANT

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: G7N11T8O78

Structure
InChI Key NXFFJDQHYLNEJK-CYBMUJFWSA-N
Smile CS(=O)(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3
InChI
InChI=1S/C21H19ClFNO4S/c1-29(27,28)18-10-15(23)9-17-16-7-4-13(8-19(25)26)20(16)24(21(17)18)11-12-2-5-14(22)6-3-12/h2-3,5-6,9-10,13H,4,7-8,11H2,1H3,(H,25,26)/t13-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C21H19ClFNO4S
Molecular Weight 435.9
AlogP 4.39
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 5.0
Polar Surface Area 76.37
Molecular species ACID
Aromatic Rings 3.0
Heavy Atoms 29.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Prostanoid DP receptor antagonist PubMed Other
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Lipid-like ligand receptor (family A GPCR) Prostanoid receptor
- 0-4 0 1 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Hyperlipidemia, Familial Combined 3 D006950 ClinicalTrials
Hypercholesterolemia 3 D006937 ClinicalTrials
Diabetes Mellitus, Type 2 3 D003924 ClinicalTrials
Hyperlipidemias 3 D006949 ClinicalTrials
Hyperlipoproteinemia Type II 3 D006938 ClinicalTrials
Lipid Metabolism Disorders 3 D052439 ClinicalTrials
Flushing 2 D005483 ClinicalTrials
Rosacea 1 D012393 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 571170-77-9
ChEBI 135942
ChEMBL CHEMBL426559
DrugBank DB11629
DrugCentral 4326
EPA CompTox DTXSID60205756
FDA SRS G7N11T8O78
Guide to Pharmacology 3356
PharmGKB PA166129564
PubChem 9867642
SureChEMBL SCHEMBL991107
ZINC ZINC000003961849
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