Synonyms: | |
Status: | Approved (2017) |
Entry Type: | Small molecule |
Molecule Category: | Parent |
ATC: | S01EX05 |
UNII: | W6I5QDT7QI |
InChI Key | APPRZRMVUBRYNF-ZTDHTWSHSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C28H27N3O3 |
Molecular Weight | 453.54 |
AlogP | 4.89 |
Hydrogen Bond Acceptor | 5.0 |
Hydrogen Bond Donor | 2.0 |
Number of Rotational Bond | 7.0 |
Polar Surface Area | 94.31 |
Molecular species | BASE |
Aromatic Rings | 4.0 |
Heavy Atoms | 34.0 |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Enzyme
Kinase
Protein Kinase
AGC protein kinase group
AGC protein kinase DMPK family
AGC protein kinase ROCK subfamily
|
- | - | - | 4 | - |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Fuchs' Endothelial Dystrophy | 3 | D005642 | ClinicalTrials |
Corneal Edema | 2 | D015715 | ClinicalTrials |
Glaucoma, Open-Angle | 0 | D005902 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 1254032-66-0 |
ChEMBL | CHEMBL4594250 |
DrugCentral | 5269 |
FDA SRS | W6I5QDT7QI |
Guide to Pharmacology | 9322 |
PubChem | 66599893 |
SureChEMBL | SCHEMBL16036278 |
ZINC | ZINC000113149554 |