RIVICICLIB

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 9EK26WE8QN

Structure
InChI Key QLUYMIVVAYRECT-UHFFFAOYSA-N
Smile CN1CCC(c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)C1CO
InChI
InChI=1S/C21H20ClNO5/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C21H20ClNO5
Molecular Weight 401.85
AlogP 3.3
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 3.0
Polar Surface Area 94.14
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 28.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Cyclin-dependent kinase 1 inhibitor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase CDK family CMGC protein kinase CDC2 subfamily
- 224 - - -
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase CDK family CMGC protein kinase CDK9 subfamily
- 20 - - -
Enzyme Kinase Protein Kinase CMGC protein kinase group
- 20 - - -
Other cytosolic protein
- 20 - - -

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL3545283
FDA SRS 9EK26WE8QN
PubChem 24887371
SureChEMBL SCHEMBL665748
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