| Status: | Phase 1 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | 8EOO6HQF8Y |
Structure
| InChI Key | PEMUGDMSUDYLHU-ZEQRLZLVSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C32H35ClFN7O2 |
| Molecular Weight | 604.13 |
| AlogP | 4.73 |
| Hydrogen Bond Acceptor | 8.0 |
| Hydrogen Bond Donor | 0.0 |
| Number of Rotational Bond | 7.0 |
| Polar Surface Area | 88.83 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 43.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | GTPase KRas inhibitor | PubMed |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Carcinoma, Non-Small-Cell Lung | 3 | D002289 | ClinicalTrials |
Related Entries
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL4594350 |
| FDA SRS | 8EOO6HQF8Y |
| Guide to Pharmacology | 10888 |
| SureChEMBL | SCHEMBL20974691 |
CONTENTS