CHLOROPHENYLPIPERAZINE

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: REY0CNO998

Structure
InChI Key VHFVKMTVMIZMIK-UHFFFAOYSA-N
Smile Clc1cccc(N2CCNCC2)c1
InChI
InChI=1S/C10H13ClN2/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13/h1-3,8,12H,4-7H2

Physicochemical Descriptors

Property Name Value
Molecular Formula C10H13ClN2
Molecular Weight 196.68
AlogP 1.75
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 1.0
Polar Surface Area 15.27
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 13.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel 5HT3 receptor
- - - 62 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor
- 18000 - 236 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
8-170 - 100 23-2400 -
Membrane receptor
8-170 18000 100 23-2400 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family
- - - 271 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Cocaine-Related Disorders 2 D019970 ClinicalTrials
Alcoholism 2 D000437 ClinicalTrials

Cross References

Resources Reference
ChEBI 10588
ChEMBL CHEMBL478
DrugBank DB12110
EPA CompTox DTXSID9045138
FDA SRS REY0CNO998
Human Metabolome Database HMDB0061008
Guide to Pharmacology 142
KEGG C11738
SureChEMBL SCHEMBL48931
ZINC ZINC000000004285
CONTENTS