| Synonyms: | |
| Status: | Approved (2024) |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | JM8C1SFX0U |
Structure
| InChI Key | PIBARDGJJAGJAJ-NQIIRXRSSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C26H23BrFN7O3 |
| Molecular Weight | 580.42 |
| AlogP | 3.74 |
| Hydrogen Bond Acceptor | 8.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 6.0 |
| Polar Surface Area | 122.97 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 4.0 |
| Heavy Atoms | 38.0 |
Pharmacology
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Protease
Serine protease
|
- | 4-15 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Hemoglobinuria, Paroxysmal | 3 | D006457 | ClinicalTrials |
| Glomerulonephritis, Membranoproliferative | 2 | D015432 | ClinicalTrials |
| Liver Diseases | 1 | D008107 | ClinicalTrials |
| Kidney Diseases | 1 | D007674 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL4250860 |
| DrugBank | DB15401 |
| FDA SRS | JM8C1SFX0U |
| PubChem | 118323590 |
| SureChEMBL | SCHEMBL17024981 |
CONTENTS