Synonyms: | |
Status: | Phase 2 |
Entry Type: | Small molecule |
Molecule Category: | UNKNOWN |
UNII: | 3B974D670O |
InChI Key | IPEXHQGMTHOKQV-UHFFFAOYSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C14H17ClN2O2 |
Molecular Weight | 280.76 |
AlogP | 1.66 |
Hydrogen Bond Acceptor | 3.0 |
Hydrogen Bond Donor | 2.0 |
Number of Rotational Bond | 2.0 |
Polar Surface Area | 54.12 |
Molecular species | BASE |
Aromatic Rings | 2.0 |
Heavy Atoms | 18.0 |
Action | Mechanism of Action | Reference |
---|---|---|
INHIBITOR | Rho-associated protein kinase inhibitor | PubMed |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Enzyme
Kinase
Protein Kinase
AGC protein kinase group
AGC protein kinase DMPK family
AGC protein kinase ROCK subfamily
|
- | 186 | - | - | - |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Erectile Dysfunction | 2 | D007172 | ClinicalTrials |
Coronary Disease | 2 | D003327 | ClinicalTrials |
Renal Insufficiency, Chronic | 1 | D051436 | ClinicalTrials |
Resources | Reference |
---|---|
ChEMBL | CHEMBL3545341 |
EPA CompTox | DTXSID80655294 |
FDA SRS | 3B974D670O |
PubChem | 15604510 |
SureChEMBL | SCHEMBL952603 |
ChEMBL | CHEMBL1667969 |
FDA SRS | 3B974D670O |
Guide to Pharmacology | 8910 |
PubChem | 15604510 |
SureChEMBL | SCHEMBL952213 |
ZINC | ZINC000034603838 |