CAPMATINIB HYDROCHLORIDE

Search structure
Synonyms:
Status: Approved (2020)
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: C2A374O70X

Structure
InChI Key COWBUPJEEDYWKD-UHFFFAOYSA-N
Smile CNC(=O)c1ccc(-c2cnc3ncc(Cc4ccc5ncccc5c4)n3n2)cc1F.Cl.Cl.O
InChI
InChI=1S/C23H17FN6O.2ClH.H2O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20;;;/h2-9,11-13H,10H2,1H3,(H,25,31);2*1H;1H2

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H21Cl2FN6O2
Molecular Weight 503.37
AlogP 3.43
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 4.0
Polar Surface Area 85.07
Molecular species NEUTRAL
Aromatic Rings 5.0
Heavy Atoms 31.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Hepatocyte growth factor receptor inhibitor FDA

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Carcinoma, Non-Small-Cell Lung 4 D002289 FDA

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL3989937
FDA SRS C2A374O70X
PubChem 122201352
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