MIZOLASTINE

Search structure
Synonyms:
Status: Approved
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: R06AX25
UNII: 244O1F90NA

Structure
InChI Key PVLJETXTTWAYEW-UHFFFAOYSA-N
Smile CN(c1nccc(=O)[nH]1)C1CCN(c2nc3ccccc3n2Cc2ccc(F)cc2)CC1
InChI
InChI=1S/C24H25FN6O/c1-29(23-26-13-10-22(32)28-23)19-11-14-30(15-12-19)24-27-20-4-2-3-5-21(20)31(24)16-17-6-8-18(25)9-7-17/h2-10,13,19H,11-12,14-16H2,1H3,(H,26,28,32)

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H25FN6O
Molecular Weight 432.5
AlogP 3.41
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 5.0
Polar Surface Area 70.05
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 32.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Histamine H1 receptor antagonist Other PubMed Other PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- 350-441 - 7258 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Histamine receptor
- - - 3 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 31857
ChEMBL CHEMBL94454
DrugBank DB12523
DrugCentral 1824
EPA CompTox DTXSID5046801
FDA SRS 244O1F90NA
Human Metabolome Database HMDB0240233
Guide to Pharmacology 10102
PharmGKB PA166129535
PubChem 65906
SureChEMBL SCHEMBL5061
ZINC ZINC000013831810
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