| Synonyms: | |
| Status: | Phase 1 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | OLJ18SRI8A |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C26H32BrF3N8O |
| Molecular Weight | 609.5 |
| AlogP | 4.78 |
| Hydrogen Bond Acceptor | 8.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 9.0 |
| Polar Surface Area | 93.28 |
| Molecular species | None |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 39.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Ribosomal protein S6 kinase (P70S6K) inhibitor |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Kinase
Protein Kinase
AGC protein kinase group
AGC protein kinase AKT family
|
- | 1-194 | - | - | - | |
|
Enzyme
Kinase
Protein Kinase
AGC protein kinase group
AGC protein kinase RSK family
AGC protein kinase p70 subfamily
|
- | 2-55 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Neoplasms | 1 | D009369 | ClinicalTrials |
| Neoplasms | 1 | D009369 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL3544935 |
| FDA SRS | OLJ18SRI8A |
| PubChem | 56963011 |
CONTENTS