| Synonyms: | |
| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | 64CW205BDD |
Structure
| InChI Key | LNLJHGXOFYUARS-OAQYLSRUSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C23H14ClF3N6O |
| Molecular Weight | 482.85 |
| AlogP | 5.24 |
| Hydrogen Bond Acceptor | 6.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 4.0 |
| Polar Surface Area | 90.53 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 5.0 |
| Heavy Atoms | 34.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | PI3-kinase p110-delta subunit inhibitor | PubMed |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Transferase
|
- | 12 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Sjogren's Syndrome | 2 | D012859 | ClinicalTrials |
| Psoriasis | 1 | D011565 | ClinicalTrials |
Related Entries
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL4297648 |
| DrugBank | DB12706 |
| FDA SRS | 64CW205BDD |
| Guide to Pharmacology | 9800 |
| PubChem | 56928390 |
| SureChEMBL | SCHEMBL15363617 |
CONTENTS