POZANICLINE

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: CL2002R563

Structure
InChI Key YRVIKLBSVVNSHF-JTQLQIEISA-N
Smile Cc1ncccc1OC[C@@H]1CCCN1
InChI
InChI=1S/C11H16N2O/c1-9-11(5-3-6-12-9)14-8-10-4-2-7-13-10/h3,5-6,10,13H,2,4,7-8H2,1H3/t10-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C11H16N2O
Molecular Weight 192.26
AlogP 1.52
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 3.0
Polar Surface Area 34.15
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 14.0

Pharmacology

Action Mechanism of Action Reference
PARTIAL AGONIST Neuronal acetylcholine receptor; alpha6/beta2 partial agonist Wikipedia PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor Nicotinic acetylcholine receptor alpha subunit
- - - 16-39 -
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor Nicotinic acetylcholine receptor beta subunit
- - - 16-39 -
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor Nicotinic acetylcholine receptor delta subunit
30000 - - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Alzheimer Disease 2 D000544 ClinicalTrials
Attention Deficit Disorder with Hyperactivity 2 D001289 ClinicalTrials
Tobacco Use Disorder 2 D014029 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL127071
DrugBank DB05458
EPA CompTox DTXSID20167149
FDA SRS CL2002R563
PubChem 178052
SureChEMBL SCHEMBL194037
ZINC ZINC000000006562
CONTENTS