Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: T3U32GLJ0F

Structure

InChI Key VFBILHPIHUPBPZ-UHFFFAOYSA-N
Smile CCOc1ccccc1C(=O)NCc1coc(-c2ccc(OC(F)F)c(OC(C)C)c2)n1
InChI
InChI=1S/C23H24F2N2O5/c1-4-29-18-8-6-5-7-17(18)21(28)26-12-16-13-30-22(27-16)15-9-10-19(32-23(24)25)20(11-15)31-14(2)3/h5-11,13-14,23H,4,12H2,1-3H3,(H,26,28)

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H24F2N2O5
Molecular Weight 446.45
AlogP 5.06
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 10.0
Polar Surface Area 82.82
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 32.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Phosphodiesterase 4 inhibitor PubMed PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Dermatitis, Atopic 3 D003876 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL3989968
DrugBank DB14987
FDA SRS T3U32GLJ0F
Guide to Pharmacology 9776
PubChem 57855696
SureChEMBL SCHEMBL4275421