AZD-1656

Search structure


Synonyms:	Azd 1656 Azd-1656 Azd1656 AZD1656
Status:	Phase 2
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	660M185X4D

Structure


InChI Key	FJEJHJINOKKDCW-INIZCTEOSA-N
Smile	COC[C@H](C)Oc1cc(Oc2cnc(C(=O)N3CCC3)cn2)cc(C(=O)Nc2cnc(C)cn2)c1
InChI	InChI=1S/C24H26N6O5/c1-15-10-27-21(12-25-15)29-23(31)17-7-18(34-16(2)14-33-3)9-19(8-17)35-22-13-26-20(11-28-22)24(32)30-5-4-6-30/h7-13,16H,4-6,14H2,1-3H3,(H,27,29,31)/t16-/m0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C24H26N6O5
Molecular Weight	478.51
AlogP	2.88
Hydrogen Bond Acceptor	9.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	9.0
Polar Surface Area	128.66
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	35.0

Pharmacology

Action	Mechanism of Action	Reference
ACTIVATOR	Hexokinase type IV activator	PubMed Other

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme	28-61	-	11	-	-

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Diabetes Mellitus, Type 2	2	D003924	ClinicalTrials
Severe Acute Respiratory Syndrome	2	D045169	ClinicalTrials
Diabetes Mellitus, Type 1	1	D003922	ClinicalTrials

Cross References

Resources	Reference
ChEMBL	CHEMBL3219124
DrugBank	DB14810
FDA SRS	660M185X4D
Guide to Pharmacology	7701
PubChem	16039797
SureChEMBL	SCHEMBL321593

CONTENTS