| Synonyms: | |
| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | Y7W5AL9KHB |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C16H13FN4O2 |
| Molecular Weight | 312.3 |
| AlogP | 3.51 |
| Hydrogen Bond Acceptor | 6.0 |
| Hydrogen Bond Donor | 4.0 |
| Number of Rotational Bond | 4.0 |
| Polar Surface Area | 90.3 |
| Molecular species | None |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 23.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Tyrosine-protein kinase SYK inhibitor |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase Syk family
|
115-2010 | 290-300 | - | 96-96 | - | |
|
Enzyme
Transferase
|
- | - | - | - | 10.14 | |
|
Epigenetic regulator
Eraser
Histone deacetylase
HDAC class IIb
|
- | - | - | - | -1.77--0.51 |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL3545399 |
| FDA SRS | Y7W5AL9KHB |
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