FUTIBATINIB

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Synonyms:	Fgfr-in-1 Futibatinib Tas 120 Tas-120 TAS-120
Status:	Approved (2022)
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	4B93MGE4AL

Structure


InChI Key	KEIPNCCJPRMIAX-HNNXBMFYSA-N
Smile	C=CC(=O)N1CC[C@H](n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1
InChI	InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/m0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C22H22N6O3
Molecular Weight	418.46
AlogP	1.78
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	4.0
Polar Surface Area	108.39
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	31.0

Pharmacology

Action	Mechanism of Action	Reference
INHIBITOR	Fibroblast growth factor receptor inhibitor	PubMed Other

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Cholangiocarcinoma	3	D018281	ClinicalTrials
Sarcoma	3	D012509	ClinicalTrials
Neoplasms	2	D009369	ClinicalTrials
Breast Neoplasms	2	D001943	ClinicalTrials
Neoplasms	2	D009369	ClinicalTrials
Carcinoma, Hepatocellular	2	D006528	ClinicalTrials
Carcinoma, Non-Small-Cell Lung	1	D002289	ClinicalTrials

Cross References

Resources	Reference
ChEMBL	CHEMBL3701238
DrugBank	DB15149
FDA SRS	4B93MGE4AL
Guide to Pharmacology	9786
PDB	TZ0
PubChem	71621331
SureChEMBL	SCHEMBL15345470
ZINC	ZINC000207800318

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