AVADOMIDE

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 28DZS29F59

Structure
InChI Key RSNPAKAFCAAMBH-UHFFFAOYSA-N
Smile Cc1nc2cccc(N)c2c(=O)n1C1CCC(=O)NC1=O
InChI
InChI=1S/C14H14N4O3/c1-7-16-9-4-2-3-8(15)12(9)14(21)18(7)10-5-6-11(19)17-13(10)20/h2-4,10H,5-6,15H2,1H3,(H,17,19,20)

Physicochemical Descriptors

Property Name Value
Molecular Formula C14H14N4O3
Molecular Weight 286.29
AlogP 0.26
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 1.0
Polar Surface Area 107.08
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 21.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Unclassified protein
- 38700 - 16700 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Melanoma 2 D008545 ClinicalTrials
Lymphoma, Follicular 1 D008224 ClinicalTrials
Carcinoma, Hepatocellular 1 D006528 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 1 D016403 ClinicalTrials
Lymphoma, Non-Hodgkin 1 D008228 ClinicalTrials
Renal Insufficiency 1 D051437 ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-Cell 1 D015451 ClinicalTrials
Lymphoma, Follicular 1 D008224 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL3989934
DrugBank DB14857
FDA SRS 28DZS29F59
Guide to Pharmacology 10522
PubChem 24967599
SureChEMBL SCHEMBL282749
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