CO-TRIMOXAZOLE

Search structure


Status:	Phase 3
Entry Type:	Small molecule
Molecule Category:	UNKNOWN

Structure


InChI Key	WZRJTRPJURQBRM-UHFFFAOYSA-N
Smile	COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC.Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1
InChI	InChI=1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C25H30N6O6S
Molecular Weight	542.62
AlogP	None
Hydrogen Bond Acceptor	None
Hydrogen Bond Donor	None
Number of Rotational Bond	None
Polar Surface Area	None
Molecular species	None
Aromatic Rings	None
Heavy Atoms	None

Pharmacology

Action	Mechanism of Action	Reference
INHIBITOR	Bacterial dihydrofolate reductase inhibitor

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Peritonitis	3	D010538	ClinicalTrials
Sepsis	3	D018805	ClinicalTrials
Bacterial Infections	3	D001424	ClinicalTrials
Lung Diseases	2	D008171	ClinicalTrials
Tuberculosis	2	D014376	ClinicalTrials
Pneumonia, Pneumocystis	2	D011020	ClinicalTrials
Severe Acute Respiratory Syndrome	2	D045169	ClinicalTrials

Cross References

Resources	Reference
ChEMBL	CHEMBL195591

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