AMG-232

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 7R7G6EH5UL

Structure
InChI Key DRLCSJFKKILATL-YWCVFVGNSA-N
Smile CC(C)[C@@H](CS(=O)(=O)C(C)C)N1C(=O)[C@@](C)(CC(=O)O)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1
InChI
InChI=1S/C28H35Cl2NO5S/c1-17(2)24(16-37(35,36)18(3)4)31-26(19-9-11-21(29)12-10-19)23(20-7-6-8-22(30)13-20)14-28(5,27(31)34)15-25(32)33/h6-13,17-18,23-24,26H,14-16H2,1-5H3,(H,32,33)/t23-,24-,26-,28-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C28H35Cl2NO5S
Molecular Weight 568.56
AlogP 6.38
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 9.0
Polar Surface Area 91.75
Molecular species ACID
Aromatic Rings 2.0
Heavy Atoms 37.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Tumour suppressor p53/oncoprotein Mdm2 inhibitor PubMed PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Other nuclear protein
- 1-47 0-0 - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Carcinoma, Merkel Cell 2 D015266 ClinicalTrials
Primary Myelofibrosis 2 D055728 ClinicalTrials
Polycythemia Vera 2 D011087 ClinicalTrials
Primary Myelofibrosis 2 D055728 ClinicalTrials
Thrombocythemia, Essential 2 D013920 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials
Leukemia, Myelogenous, Chronic, BCR-ABL Positive 1 D015464 ClinicalTrials
Leukemia, Myeloid, Acute 1 D015470 ClinicalTrials
Melanoma 1 D008545 ClinicalTrials
Gliosarcoma 1 D018316 ClinicalTrials
Sarcoma 1 D012509 ClinicalTrials
Multiple Myeloma 1 D009101 ClinicalTrials
Plasmacytoma 1 D010954 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL3125702
DrugBank DB15299
FDA SRS 7R7G6EH5UL
Guide to Pharmacology 11133
SureChEMBL SCHEMBL9993310
ZINC ZINC000103248035
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