| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C18H10FN3S |
| Molecular Weight | 319.36 |
| AlogP | 3.92 |
| Hydrogen Bond Acceptor | 4.0 |
| Hydrogen Bond Donor | 0.0 |
| Number of Rotational Bond | 1.0 |
| Polar Surface Area | 49.57 |
| Molecular species | None |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 23.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| NEGATIVE ALLOSTERIC MODULATOR | Metabotropic glutamate receptor 5 negative allosteric modulator |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Membrane receptor
Family C G protein-coupled receptor
Small molecule receptor (family C GPCR)
Neurotransmitter receptor (family C GPCR)
Metabotropic glutamate receptor
|
- | - | - | 20 | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Fragile X Syndrome | 2 | D005600 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL3545037 |
CONTENTS