RESEQUINIL

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 2G222T03EY

Structure
InChI Key JQOFKKWHXGQABB-UHFFFAOYSA-N
Smile COc1cccc(-c2nccc3[nH]c(=O)c(-c4noc(C)n4)cc23)c1
InChI
InChI=1S/C18H14N4O3/c1-10-20-17(22-25-10)14-9-13-15(21-18(14)23)6-7-19-16(13)11-4-3-5-12(8-11)24-2/h3-9H,1-2H3,(H,21,23)

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H14N4O3
Molecular Weight 334.34
AlogP 2.96
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 3.0
Polar Surface Area 93.9
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 25.0

Pharmacology

Action Mechanism of Action Reference
INVERSE AGONIST GABA-A receptor; anion channel inverse agonist PubMed Wikipedia

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Alzheimer Disease 2 D000544 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL2107801
FDA SRS 2G222T03EY
SureChEMBL SCHEMBL677466
ZINC ZINC000000007384
CONTENTS