| Synonyms: | |
| Status: | Phase 1 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C9H8BrN7 |
| Molecular Weight | 294.12 |
| AlogP | 0.45 |
| Hydrogen Bond Acceptor | 7.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 3.0 |
| Polar Surface Area | 94.54 |
| Molecular species | None |
| Aromatic Rings | 2.0 |
| Heavy Atoms | 17.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| ANTAGONIST | Adenosine A2a receptor antagonist | Other |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Phosphodiesterase
Phosphodiesterase 10
Phosphodiesterase 10A
|
- | 5.8 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Huntington Disease | 1 | D006816 | ClinicalTrials |
| Neoplasms | 1 | D009369 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL3545271 |
CONTENTS