APAZONE

Search structure
Synonyms:
Status: Approved
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: K2VOT966ZI

Structure
InChI Key MPHPHYZQRGLTBO-UHFFFAOYSA-N
Smile CCCC1C(=O)N2C(N(C)C)=Nc3ccc(C)cc3N2C1=O
InChI
InChI=1S/C16H20N4O2/c1-5-6-11-14(21)19-13-9-10(2)7-8-12(13)17-16(18(3)4)20(19)15(11)22/h7-9,11H,5-6H2,1-4H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C16H20N4O2
Molecular Weight 300.36
AlogP 2.06
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 2.0
Polar Surface Area 56.22
Molecular species ACID
Aromatic Rings 1.0
Heavy Atoms 22.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Cyclooxygenase inhibitor PubMed PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- - - -
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- - - - 26.33-67.93

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 38010
ChEMBL CHEMBL1565476
DrugCentral 266
EPA CompTox DTXSID6045408
FDA SRS K2VOT966ZI
PharmGKB PA166049192
PubChem 26098
SureChEMBL SCHEMBL3190
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