TAVAPADON

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: PT4P8MJP8L

Structure
InChI Key AKQXQLUNFKDZBN-UHFFFAOYSA-N
Smile Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C
InChI
InChI=1S/C19H16F3N3O3/c1-10-9-12(28-17-14(19(20,21)22)5-4-8-23-17)6-7-13(10)15-11(2)16(26)24-18(27)25(15)3/h4-9H,1-3H3,(H,24,26,27)

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H16F3N3O3
Molecular Weight 391.35
AlogP 3.56
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 3.0
Polar Surface Area 76.98
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 28.0

Pharmacology

Action Mechanism of Action Reference
PARTIAL AGONIST Dopamine D1 receptor partial agonist Other Other
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor
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Indications

Mesh Heading Maximum Phase Mesh ID Reference
Parkinson Disease 3 D010300 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL3697617
DrugBank DB14899
FDA SRS PT4P8MJP8L
PubChem 86764100
SureChEMBL SCHEMBL16334991
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