AQW051

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN

Structure
InChI Key NPDLTEZXGWRMLQ-UHFFFAOYSA-N
Smile Cc1ccc(-c2ccc(OC3CN4CCC3CC4)cn2)cc1
InChI
InChI=1S/C19H22N2O/c1-14-2-4-15(5-3-14)18-7-6-17(12-20-18)22-19-13-21-10-8-16(19)9-11-21/h2-7,12,16,19H,8-11,13H2,1H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H22N2O
Molecular Weight 294.4
AlogP 3.53
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 3.0
Polar Surface Area 25.36
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 22.0

Pharmacology

Action Mechanism of Action Reference
PARTIAL AGONIST Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist PubMed PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Schizophrenia 2 D012559 ClinicalTrials
Alzheimer Disease 2 D000544 ClinicalTrials
Cognitive Dysfunction 2 D060825 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL3545232
SureChEMBL SCHEMBL1459287
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