LY-3009120

Search structure
Synonyms:
Status: Phase 1
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 1GDT36RARO

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H29FN6O
Molecular Weight 424.52
AlogP 5.05
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 5.0
Polar Surface Area 91.83
Molecular species None
Aromatic Rings 3.0
Heavy Atoms 31.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Serine/threonine-protein kinase A-Raf inhibitor PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- 150 - - -
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase MAPK family CMGC protein kinase JNK subfamily
- 470 - - -
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase MAPK family CMGC protein kinase p38 subfamily
- 61 - - -
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase PEK family Other protein kinase GCN2 subfamily
- 450 - - -
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE11 family
- 98 - - -
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE20 family STE protein kinase KHS subfamily
- 970 - - -
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE7 family
- 800 - - -
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase IRAK family
- 390 - - -
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase MLK family TKL protein kinase MLK subfamily
- 39 - - -
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase RAF family
- 1.5-5800 - 0.061-0.061 -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Abl family
- 380 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Csk family
- 290 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Eph family
- 100 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Src family
- 310 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase VEGFR family
- 3900 - - -
Enzyme Transferase
- - - - -9.12-5.809
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- - - - 0.43-12.39

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Melanoma 1 D008545 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 1 D002289 ClinicalTrials
Colorectal Neoplasms 1 D015179 ClinicalTrials
Neoplasm Metastasis 1 D009362 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL3545195
FDA SRS 1GDT36RARO
PubChem 71721540
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