LY-3200882

Search structure


Synonyms:	Ly-3200882 Ly3200882 LY3200882
Status:	Phase 1
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	19HY34R6UN

Structure


InChI Key	PNPFMWIDAKQFPY-UHFFFAOYSA-N
Smile	CC(C)(O)c1cc(Nc2cc(Oc3cn(C4CC4)nc3C3CCOCC3)ccn2)ccn1
InChI	InChI=1S/C24H29N5O3/c1-24(2,30)21-13-17(5-9-25-21)27-22-14-19(6-10-26-22)32-20-15-29(18-3-4-18)28-23(20)16-7-11-31-12-8-16/h5-6,9-10,13-16,18,30H,3-4,7-8,11-12H2,1-2H3,(H,25,26,27)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C24H29N5O3
Molecular Weight	435.53
AlogP	4.67
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	7.0
Polar Surface Area	94.32
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	32.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase STKR family TKL protein kinase STKR Type 1 subfamily	-	38	-	-	-

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Neoplasms	1	D009369	ClinicalTrials
Neoplasms	1	D009369	ClinicalTrials

Cross References

Resources	Reference
ChEMBL	CHEMBL4594432
FDA SRS	19HY34R6UN
PubChem	121249291
SureChEMBL	SCHEMBL17645407

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