SGX-523

Search structure
Synonyms:
Status: Phase 1
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: WH8SQN09KJ

Structure
InChI Key BCZUAADEACICHN-UHFFFAOYSA-N
Smile Cn1cc(-c2ccc3nnc(Sc4ccc5ncccc5c4)n3n2)cn1
InChI
InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H13N7S
Molecular Weight 359.42
AlogP 3.22
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 3.0
Polar Surface Area 73.79
Molecular species NEUTRAL
Aromatic Rings 5.0
Heavy Atoms 26.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Hepatocyte growth factor receptor inhibitor PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase DYRK family CMGC protein kinase Dyrk1 subfamily
- - 1800 - -
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase MAPK family CMGC protein kinase JNK subfamily
- - 1900 - -
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE11 family
- - 6400 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Abl family
- - 3400 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Met family
- 3-4 0-4 - -
Enzyme Transferase
- - 3300 - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neoplasms 1 D009369 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 90624
ChEMBL CHEMBL1236107
DrugBank DB06314
EPA CompTox DTXSID70647300
FDA SRS WH8SQN09KJ
Guide to Pharmacology 5709
PDB SX8
PubChem 24779724
SureChEMBL SCHEMBL4496422
ZINC ZINC000039129916
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