PRALICIGUAT

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: R1S0H458SA

Structure
InChI Key CYSJNTQNMDWAJV-UHFFFAOYSA-N
Smile OC(CNc1nc(-c2cc(-c3ccon3)n(Cc3ccccc3F)n2)ncc1F)(C(F)(F)F)C(F)(F)F
InChI
InChI=1S/C21H14F8N6O2/c22-12-4-2-1-3-11(12)9-35-16(14-5-6-37-34-14)7-15(33-35)18-30-8-13(23)17(32-18)31-10-19(36,20(24,25)26)21(27,28)29/h1-8,36H,9-10H2,(H,30,31,32)

Physicochemical Descriptors

Property Name Value
Molecular Formula C21H14F8N6O2
Molecular Weight 534.37
AlogP 4.59
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 7.0
Polar Surface Area 101.89
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 37.0

Pharmacology

Action Mechanism of Action Reference
ACTIVATOR Soluble guanylate cyclase activator PubMed PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Heart Failure 2 D006333 ClinicalTrials

Cross References

Resources Reference
ChEBI 142431
ChEMBL CHEMBL4297214
DrugBank DB16300
FDA SRS R1S0H458SA
Guide to Pharmacology 9900
PubChem 86269973
SureChEMBL SCHEMBL16082414
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