IMD-0354

Search structure
Synonyms:
Status: Phase 1
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 76145IS906

Physicochemical Descriptors

Property Name Value
Molecular Formula C15H8ClF6NO2
Molecular Weight 383.68
AlogP 5.34
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 2.0
Polar Surface Area 49.33
Molecular species None
Aromatic Rings 2.0
Heavy Atoms 25.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- - - -
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase MLCK family
- - 3224 - -
Enzyme Kinase Protein Kinase Other protein kinase group
- 218 - - 30.5
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE20 family STE protein kinase KHS subfamily
- - 1464 - -
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase unique family
- - - - 13.8
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase PDGFR family
- - - 794.33 -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase VEGFR family
- - - 3162.28 -
Enzyme Kinase Protein kinase regulatory subunit
- - - - 40
Enzyme Protease Serine protease
- 11000 - - 45-100
Enzyme Transferase
- - - - 3.863
Enzyme
- 11000 1464 3162.28 45-100
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- - - - -0.28-3.28
Ion channel Ligand-gated ion channel P2X receptor
- 19.2-4730 - - 11
Transcription factor
- - - - 42.4-89.1
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC02 family of hexose and sugar alcohol transporters
- - - - 7.09
Transporter
- - - - 7.09

Cross References

Resources Reference
ChEMBL CHEMBL3545089
FDA SRS 76145IS906
PubChem 5081913
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